PEPTIDE ANALOGS AS SELECTIVE INHIBITORS OF THROMBIN ACTIVATION OF PROTEASE ACTIVATED RECEPTOR 1

摘要

The invention relates to inhibiting human platelet aggregation, thrombosis a nd cell activation mediated by PAR1 with peptide analogs corresponding to those of Formula I and II, wherein Formula I is: Arg-Gly-Lys-Z4-Cys (SEQ ID NO: 43 ) wherein: Z4 is any naturally occurring amino acid, excluding cysteine; and wherein Formula II is: Arg-Gly-Asp-Z4-Cys (SEQ ID NO: 44) wherein: Z4 is any naturally occurring amino acid, excluding cysteine.