ENHANCED YIELD OF PODOPHYLLOTOXIN FROM NATURAL PRODUCTS THROUGH IN SITU CONVERSION METHODS
摘要
Enhanced recovery of podophyllotoxin from biological sources is achieved through disruption or permeabilization of the physical integrity of cells and tissues in the presence of sufficient moisture so as to allow endogenous enzymes to convert podophyllotoxin glucosides to podophyllotoxin. Extraction of the podophyllotoxin from the plant material is then achieved by use of an organic solvent. Podophyllotoxin is used as an intermediate in the production of the antitumor agent etoposide and its analogues.
申请公布号
WO0112209(A1)
申请公布日期
2001.02.22
申请号
WO2000US40660
申请日期
2000.08.16
申请人
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF AGRICULTURE;THE UNIVERSITY OF MISSISSIPPI
发明人
CANEL, CAMILO;DAYAN, FRANCK, E.;MORAES, RITA, M.;BURANDT, CHARLES, L.