THE NASAL TRANSMUCOSAL DELIVERY OF PEPTIDES CONJUGATED WITH BIOCOMPATIBLE POLYMERS

摘要

The present invention relates to a pharmaceutical composition for a nasal transmucosal delivery, comprising a biocompatible polymer-biologically active peptide conjugate. The pharmaceutical composition of the present invention increases the water solubility of peptide, which is sparingly soluble in water, improves a stability by protecting from being degraded by protease, and, consequently, reduces an administration number of drug to decrease side-effects induced by drug abuse. In addition, since the pharmaceutical composition of the present invention is delivered through the nasal cavity, it allows drug activity to be expressed in a short period of time and improves a bioavailability.