| 摘要 |
<p>A novel nucleic acid delivery system is described based on purified recombinant exotoxin protein variants. A purified exotoxin variant is described that includes a receptor targeting domain and a nucleic acid affinity domain operably linked to the exotoxin protein domain. For the transfer of nucleic acid material, the nucleic acid affinity domain is preferably a polycationic domain such as polylysine. The invention also describes methods for transferring nucleic acids material to tissues of interest, i.e., mucosal cells, using the delivery system of the invention and methods for therapeutic treatment using the delivery system.</p> |
