发明名称 |
PROTECTIVE ANTIGEN OF EPSTEIN BARR VIRUS |
摘要 |
The present invention relates to the identification of a subunit vaccine to prevent or treat infection of Epstein Barr Virus. In particular, EBNA-1 was identified as a vaccine antigen. In a specific embodiment, a purified protei n corresponding to EBNA-1 elicited a strong CD4+ T cell response. The responsi ve CD4+ T cell are primarily TH1 in function. EBNA-1 is an attractive candidate for a protective vaccine against EBV, and for immunotherapy of EBV infection and neoplasms, particularly with dendritic cells charged with EBNA-1.</SDOAB >
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申请公布号 |
CA2380991(A1) |
申请公布日期 |
2001.02.22 |
申请号 |
CA20002380991 |
申请日期 |
2000.08.10 |
申请人 |
THE ROCKFELLER UNIVERSITY |
发明人 |
STEINMAN, RALPH M.;MUENZ, CHRISTIAN |
分类号 |
C12N15/09;A61K35/76;A61K39/00;A61K39/245;A61K39/39;A61K48/00;A61P31/22;A61P35/00;C07K14/05;C07K19/00;C12N15/38;(IPC1-7):C12N15/38 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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