ZWITTERIONIC POLYSACCHARIDE POLYMERS HAVING ANTIFOULING, ANTIMICROBIAL AND OPTICAL TRANSPARENCY PROPERTIES

摘要

The present invention is directed to facile method of zwitteration of polysaccharides or other polymers with carboxybetaine (CB) or another zwitterionic betaine. Zwitterionic CB functional groups were seamlessly integrated onto dextran backbone via a one pot reaction. Different degrees of substitution were achieved by repeating the reaction and controlling the ratio of reactants. CB side groups in CB-functionalized dextran (CB-Dex) can switch between cationic and zwitterionic forms under acidic and neutral conditions. The ring structure formation was confirmed by heteronuclear multiple-bond correlation (gHMBC) 2D-NMRAntifouling properties of CB-Dex were tested in the form of hydrogel using a fluorescent method. The amount of adsorbed protein decreases dramatically with the increase of CB content. For the cell attachment study, there was almost no cell attaching on the CB-Dex hydrogel surface with the higher CB content. In addition, the optical transparency of hydrogel was enhanced significantly by increasing the CB content.

主权项

1. A zwitterionic composition having excellent anti-fouling, switchability, antimicrobial and optical properties comprising:
a polymer backbone; and one or more zwitterionic moieties chemically bonded to said polymer backbone, said zwitterionic moieties further comprising a carboxybetaine group.