ADENOVIRAL VECTORS INCLUDING DNA SEQUENCES ENCODING ANGIOGENIC INHIBITORS

摘要

An adenoviral vector which includes at least one DNA sequence encoding an angiogenic inhibitor, such as endostatin. Such vectors may be employed in treating diseases or disorders associated with angiogenesis, such as cancer, vascular diseases of the eye, including diabetic retinopathy, psoriasis, arthritis, cardiovascular disease, cerebral edema and Kasabach-Merritt syndrome.