| 摘要 |
<p>The present invention provides a novel process for the crystallization of alpha -L-aspartyl-L-phenylalanine methyl ester crystals wherein initial nucleation and initial crystal growth is conducted in a controlled manner in a metastable supersaturated solution, followed by further crystal growth via a cooling crystallization step. The process disclosed herein can be performed in an industrial scale. <IMAGE></p> |
