发明名称 |
Time-specific controlled release capsule formulations and method of preparing same |
摘要 |
The present invention provides a method of achieving the time-specific delivery of a pharmaceutically active agent to a patient in need of the therapeutic effects of the pharmaceutically active agent. The method includes administering a pharmaceutical formulation comprising (a) a core including the pharmaceutically active agent to be delivered, and (b) a swellable polymeric coating layer substantially surrounding the core. The swellable polymeric coating layer delays the release of the pharmaceutically active agent from the core for a predetermined period of time dependent upon the thickness of the swellable polymeric coating layer. The swellable polymeric coating layer surrounding the core is provided by a new method which includes alternately (I) wetting the core with a binder solution, and (ii) coating the core with powdered polymeric particles a sufficient number of times to produce a time-specific dosage formulation having the desired thickness of swellable polymeric coating layer.
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申请公布号 |
US6190692(B1) |
申请公布日期 |
2001.02.20 |
申请号 |
US19970991814 |
申请日期 |
1997.12.16 |
申请人 |
BUSETTI CESARE;CRIMELLA TIZIANO |
发明人 |
BUSETTI CESARE;CRIMELLA TIZIANO |
分类号 |
A61K9/36;A61K9/22;A61K9/28;A61K9/30;A61K9/48;A61K9/50;A61K9/52;A61K9/66;(IPC1-7):A61K9/48;A61K9/14 |
主分类号 |
A61K9/36 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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