| 摘要 |
A novel class of cationic peptides having antimicrobial activity is disclosed. These peptides can be encompassed by the formulas:wherein:m is 1 to 5;n is 1 or 2;o is 2 to 5;r is 0 to 8;u is 0 or 1;X1 is Isoleucine, Leucine, Valine, Phenylalanine, Tyrosine, Tryptophan or Methionine;X2 represents Tryptophan or PhenylalanineX3 represents Arginine or Lysine;X4 represents Tryptophan or Lysine; andX5 represents Phenylalanine, Tryptophan, Arginine, Lysine, or Proline.The invention also provides a method of producing a cationic peptide variant having antimicrobial activity.
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