发明名称 |
Compositions and methods relating to DNA mismatch repair genes |
摘要 |
Genomic sequences of human mismatch repair genes are described, as are methods of detecting mutations and/or polymorphisms in those genes. Also described are methods of diagnosing cancer susceptibility in a subject, and methods of identifying and classifying mismatch-repair-defective tumors. In particular, sequences and methods relating to human mutL homologs, hMLH1 and hPMS1 genes are provided.
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申请公布号 |
US6191268(B1) |
申请公布日期 |
2001.02.20 |
申请号 |
US19940352902 |
申请日期 |
1994.12.09 |
申请人 |
DANA-FARBER CANCER INSTITUTE;OREGON HEALTH SCIENCES UNIVERSITY |
发明人 |
LISKAY ROBERT M.;BRONNER C. ERIC;BAKER SEAN M.;BOLLAG RONI J.;KOLODNER RICHARD D. |
分类号 |
G01N33/50;C07H21/04;C07K14/47;C12N15/09;C12P21/08;C12Q1/68;G01N33/53;G01N33/566;(IPC1-7):C07H21/04 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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地址 |
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