发明名称 |
Spermicidally active 5-halo-6-alkoxy-5,6-dihydro-2',3'-dideoxy-uridines and their pharamaceutical compositions |
摘要 |
Contraceptive activity as well as anti-viral protection can be provided by contraceptive compositions containing a pyrimidine-based nucleoside or nucleotide exhibiting spermicidal or sperm-immobilizing activity. In one example, the active ingredient contains a thymine ring (e.g. AZT) that has 5-halo, 6-alkoxy substitution. Additional improvements in anti-HIV activity for certain AZT derivatives are seen by providing the pentose ring of AZT with aryl phosphate substitution.
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申请公布号 |
US6191120(B1) |
申请公布日期 |
2001.02.20 |
申请号 |
US19980047609 |
申请日期 |
1998.03.25 |
申请人 |
WAYNE HUGHES INSTITUTE |
发明人 |
D'CRUZ OSMOND;UCKUN FATIH M.;VENKATACHALAM TARACAD |
分类号 |
A61K9/00;A61K31/7042;A61K31/7052;A61K31/7064;A61K31/7072;A61P15/00;A61P31/18;C07H19/06;C07H19/10;(IPC1-7):A61K31/70;C07H19/073 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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