发明名称 |
Methods of inhibiting osteoclast activity |
摘要 |
Methods of inhibiting osteoclastogenesis and the activity of osteoclasts are disclosed. Methods of treating patients who have diseases characterized bone loss are disclosed. According to the methods, an amount of a TRANCE/RANK inhibitor effective to inhibit osteoclastogenesis is administered to the patient. Pharmaceutical compositions which comprise TRANCE/RANK inhibitor in an amount effective to inhibit osteoclastogenesis. Methods of modulating dendritic cell maturation, T cell proliferation, and/or CD40 receptor systems in an individual are disclosed. The methods comprise the step of administering to the individual an amount of a TRANCE/RANK inhibitor effective to modulating dendritic cell maturation, T cell proliferation, and/or CD40 receptor systems. |
申请公布号 |
AU6384600(A) |
申请公布日期 |
2001.02.19 |
申请号 |
AU20000063846 |
申请日期 |
2000.07.28 |
申请人 |
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA |
发明人 |
RAMACHANDRAN MURALI;MARK I. GREENE;MASAHIKO KINOSAKI |
分类号 |
A61K45/00;A61K31/00;A61K31/03;A61K31/235;A61K31/565;A61K31/585;A61K38/00;A61K38/17;A61P1/02;A61P19/00;A61P19/02;A61P19/10;A61P29/00;A61P43/00;C07K5/103;C07K5/107;C07K5/113;C07K7/00;C07K14/705 |
主分类号 |
A61K45/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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