PROCESS FOR PREPARING (BIS-(TRIFLUOROMETHYL)-PHENYL)-ACETIC ACIDS AND ALKYL ESTERS THEREOF AND DIALKYL (BIS-(TRIFLUOROMETHYL)-PHENYL)-MALONATES

摘要

[Bis-(trifluoromethyl)-phenyl]-acetic acids are obtained in an advantageous manner by reacting an appropriate bromo- or iodo-bis-{trifluoromethyl)-benzene with a di-C1-C4-alkyl malonate in the presence of a deprotonating agent and a coppe r salt and hydrolysing and decarboxylating the reaction product in basic medium. It is possible to obtain a mixture of alkyl [bis-(trifluoromethyl)-phenyl]-acetate and alky l [bis-(tri- fluoromethyl)-phenyl]-malonate by admixing the reaction mixture which is present before hydrolysis and complete decarboxylation with water and acid and heating. From the mixture, it is possible to obtain alkyl [bis-(trifluoromethyl)- phenyl]-acetate by distillation under reduced pressure and dialkyl [bis-(trifluoromethyl)- phenyl]- malonate by work-up by column chromatography, fractional distillation or fil m distillation. [Bis-(trifluoromethyl)-phenyl]-malonic esters are novel compounds.