| 摘要 |
<p>Epoxyeicosatrienoic acids (EETs) are products of cytochrome P450 epoxygenases that have vasodilatory properties similar to endothelium-derived hyperpolarizing factor (EDHF). The cytochrome P450 isoform CYP2J2 was cloned and identified as a source of EETs in human endothelial cells. Physiological concentrations of EETs or overexpression of CYP2J2 decreased cytolcine-induced endothelial cell adhesion molecule expression and prevented subsequent leukocyte adhesion to the vascular wall by a mechanism involving inhibition of transcription factor NF-λB and IλB kinase (IKK). The inhibitory effects of EETs were independent of their membrane hypopolarizing effects suggesting that these molecules play an important non-vasodilatory role in vascular inflammation.</p> |
