MONOMERIC PROTEIN OF THE TGF-.BETA. FAMILY

摘要

The present invention is concerned with proteins selected from the members o f the TGF-.beta. superfamily, which are monomeric due to substitution or deletion of a cysteine which is responsible for dimer formation. The inventi on is also concerned with nucleic acids, encoding such monomeric proteins, vectors or host cells containing the nucleic acids as well as with pharmaceutical compositions comprising the proteins or nucleic acids encodin g the proteins. The pharmaceutical compositions can be applied advantageously for all indications for which the respective dimeric proteins are useful.