| 摘要 |
<p>A continuous process for producing microspheres containing an active agent wherein the microspheres have an average cross sectional porosity of less than 5 % of the total cross sectional area. The microspheres are effective for releasing active agent at a constant and highly uniform rate into a surrounding physiological medium. The microspheres comprise a homopolymer of lactic acid or a copolymer of glycolic and lactic acids. An active agent is homogeneously distributed within a matrix of the homopolymer or copolymer wherein an average number and size of the active agent in a particular unit area is substantially the same as a second average number and size of the active agent in a different unit area of the microsphere.</p> |
