DEPOT FORMS OF MODIFIED NUCLEOSIDE 5'-HYDROGENPHOSPHATES AS INHIBITORS OF REPRODUCTION OF HUMAN IMMUNODEFICIENCY VIRUS AND HUMAN HEPATITIS B VIRUS

摘要

The present invention is directed to novel compounds exhibiting a selective inhibition of the reproduction of HIV and HBV and possessing low toxicity. The present compounds are VI-VIII of formulae (VI, VII and VIII) wherein: Nucleosides of D and L-series; B = thymine, adenine, guanine, cytosine, uracyl, 5-fluorouracyl or 5-ethyluracyl; R = N3, NH2, F, H or F; X = S or O; R = adamantyl-1, bicyclo[6,5,1] heptyl-1 or tert.-butyl. These compounds being depot forms of 5'-hydrogenphosphonates of modified nucleosides are able to inhibit the reproduction of HIV and HBV and are less toxic as compared to the prior art compounds.