Verfahren zur Nutzung von Dendrimeren als Multiplikatoren zur Verabreichung von Photosensibilisatoren

摘要

A method for enhanced PhotoDynamic Therapy (PDT) treatments by applying dendrimer-photosensitizer complexes to bring multiple phototosensitizer moieties to a treatment site is provided. Photosensitizers are covalently coupled to the peripheral bonding places of dendrimers and are being separated in one or more successive cycles. Tetrapyrroles are the photosensitizers employed. In one embodiment the complex is also bound to an antibody or antibody fragment, which aids in targeting the complex to a desired treatment site. After application, the photosensitizers are released, at the treatment site, from the complexes by either light, chemical, or a combined light/chemical effect. Generally the photosensitizers develop their full photodynamic activity as free molecules after being released from the complex. More than one type of photosensitizer may be bound in the complexes. Release and/or activation may be done in a single step or with repeated steps.