MEANS FOR CREATING A MASS HAVING STRUCTURAL INTEGRITY

摘要

The present invention relates to a rapidly disintegratable tablet for administration with or without the use of water. The tablet comprises at lea st one active substance and a mixture of excipients. The excipients provide desired characteristics and physical properties and when the tablet is sintered, excellent tablet binding characteristics are obtained. The tablet is intended for oral administration and dissolves in the presence of water. Als o disclosed is a process for the preparation of a rapidly disintegratable tabl et for administration with or without the use of water. The process comprising dissolving at least one carbohydrate and at least one structuring protein or polymer in a suitable solvent, wherein the solvent provides high porosity up on drying; spray-drying said dissolved mixture to obtain matrix or bead; dry blending at least one binding polymer, and at least one active drug with the matrix or bead to obtain a pretableting formulation or adding at least one active drug to the matrix or bead dissolved or dispersed components before spray-drying; compressing the formulation to obtain a tablet; and sintering the tablet for a sufficient time and temperature to allow the binding polyme r to change status or melt and allow the polymer to resolidify as the temperature is reduced toambient temperature.