| 摘要 |
PROBLEM TO BE SOLVED: To obtain, in high yield, the subject compound useful as an intermediate for medicines, by reducing a specific dioxoctahydropyrrolopyridine using a hydroborate salt in the presence of a specific halide. SOLUTION: This compound of formula II (e.g. 6-benzyloctahydropyrrolo[3,4- b]pyridine) is obtained by reducing a 5,7-dioxoctahydropyrrolo[3,4-b]pyridine of formula I (R1 to R3 are each H or a lower alkyl; and R4 is an aralkyl) (e.g. 6-benzyl-5,7-dioxoctahydropyrrolo[3,4-b]pyridine), normally in a solvent such as tetrahydrofuran, in the presence of a halide of at least one kind of a metal element selected from 3-14 group elements (except platinum group elements) (e.g. aluminum chloride), using a hydroborate such as sodium borohydride at preferably 0 to 40 deg.C, for, in general, about 1 to 5 h.
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