| 摘要 |
The invention relates to processes for preparing 2-aminomethyl-4-cyanothiazole and its salts of the formulae Ia and Ibin whichn=1 or 2 and,for n=1, X is chloride, bromide, triflate and hydrogen sulfate andfor n=2, X is sulfate, comprising the process step where the thioamide of the formula IVis stirred with a bromopyruvate of the formula V,in which R<1 >is branched or linear C1-4-alkyl in an alcohol R<2>OH in which R<2 >is branched or linear C1-8-alkyl, HO-CH2-CH2-, HO-CH2-CH2-CH2- or C1-4-alkyl- O-CH2-CH2- at from -5° C. to 40° C. until the conversion of the thioamide IV has essentially gone to completion, and to the compounds of the formulae Ia and Ib. |
