| 摘要 |
PROBLEM TO BE SOLVED: To obtain the subject inhibitor, a medicament capable of exhibiting excellent growth inhibitory action on periodontosis-related pathogenic bacteria involved in bacterial plaque production and periodontosis onset by including, as active ingredient, an extract of guava leaves. SOLUTION: This inhibitor contains, as active ingredient, an extract of guava leaves. The guava leaves to be used are pref. dried and ground ones. The extract can easily be obtained, for example, by subjecting guava leaves to extraction treatment with water, a hydrophilic organic solvent or a mixture thereof, and the extract thus obtained contain pref. >=1 wt.%, more pref. >=3 wt.% of total polyphenols. The proportion of this inhibitor to be formulated in an oral cavity composition for inhibiting periodontosis is pref. 0.001-5 wt.% calculated as the above extract. Thereby, onset inhibition for chronic gingivitis and pyrorrhea alveolaris can be expected. |
