VANADIUM COMPOUNDS AS ANTI-ANGIOGENICS AND AS INHIBITORS OF ENDOTHELIN PRODUCTION

摘要

This invention describes the use of vanadium compounds as anti-angiogenic s. Biperoxovanadium compounds are preferred since they are more potent than the "oxo" compounds and less toxic than the latter. Anti-angiogenic activity has been verified in vitro against human umbilical vascular endothelial cells as well as ex ovo i n the chicken chorioallantoic assay membrane. The vanadium compounds also inhibit the endothelin plasmatic increase after insulin stimulation in rats. It is proposed that vanadium compounds are valuable therapeutically active anti-angiogenics by acting int er alia either on the proliferation of endothelial cells, or the secretion of endothelins, or both.