| 摘要 |
organic chemistry, pharmacy. SUBSTANCE: invention describes novel compounds of the formula (I) where R1 means -alkyl, halogen-(-alkyl), -alkynyl, hydroxy-(-alkynyl), phenyl, naphthyl, heteroaryl taken among the group including thienyl, pyridyl, thiazolyl, benzothiazolyl; R2 means H or -alkyl; R3 means naphthyl or phenyl possibly substituted with one or two -alkyls, halogen atom, -alkoxyl, hydroxyl, heteroaryl taken among the group including thienyl, 2,3-dihydro- -benzofuranyl; X is oxygen atom and Y means the direct bond, or , or their pharmaceutically acceptable salts. These compounds are antagonists of muscarinic receptors and can be used in treatment of patients with irritable bowel syndrome and enuresis. Also, these compounds can be used as recognition enhancers. EFFECT: improved method of synthesis, valuable pharmacological properties. 18 cl, 27 ex |
