发明名称 |
OLIGONUCLEOTIDE DERIVATIVES DIRECTED AGAINST HUMAN BCL-XL AND HUMAN BCL-2 MRNA |
摘要 |
The present invention relates to antisense oligonucleotide derivatives directed against human bcl-xL mRNA and being capable of modulating the biosynthesis of human bcl-xL protein. Furthermore, the present invention relates to antisense oligonucleotide derivatives directed against both human bcl-xL nRNA and human bcl-2 mRNA, and being capable of modulating the biosynthesis of both human bcl-xl protein and human bcl-2 protein. The present invention further relates to a pharmaceutical composition comprising such oligonucleotide derivatives, uses thereof and methods of treatment and diagnosis utilizing such oligonucleotide derivatives.
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申请公布号 |
WO0066724(A3) |
申请公布日期 |
2001.02.08 |
申请号 |
WO2000EP03708 |
申请日期 |
2000.04.26 |
申请人 |
UNIVERSITAET ZUERICH;ZANGEMEISTER-WITTKE, UWE;LUEDKE, GERD;HUESKEN, DIETER |
发明人 |
ZANGEMEISTER-WITTKE, UWE;LUEDKE, GERD;HUESKEN, DIETER |
分类号 |
A61P35/00;C12N15/113;(IPC1-7):C12N15/11;C07K14/82;A61K31/70;A61K48/00 |
主分类号 |
A61P35/00 |
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