The present invention relates to the use of xenon as a neuroprotectant and/or as an inhibitor of synaptic plasticity. In a preferred aspect, the xenon acts as an NMDA antagonist. The present invention also provides a method of reducing the level of activation of the NMDA receptors in a mammal, the method comprising modulating the activity of the NMDA receptor by administering to the mammal a therapeutically effective amount of xenon, wherein said reduction achieves neuroprotection and/or an inhibition of synaptic plasticity. A further embodiment of the invention provides a pharmaceutical composition for providing neuroprotection and/or inhibition of synaptic plasticity, together with a process for the process for the preparation thereof.
申请公布号
WO0108692(A1)
申请公布日期
2001.02.08
申请号
WO2000GB02896
申请日期
2000.07.28
申请人
IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE;FRANKS, NICHOLAS, PETER;MAZE, MERVYN