发明名称 |
HUMAN MONOCLONAL ANTIBODIES TO PROSTATE SPECIFIC MEMBRANE ANTIGEN |
摘要 |
Isolated human monoclonal antibodies and antigen-binding portions thereof which specifically bind to PSMA are disclosed. Also disclosed are bispecifics which include the antibodies or antibody portions. The human antibodies can be produced in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antobodies, and therapeutic and diagnostic methods for using the human antibodies.
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申请公布号 |
WO0109192(A1) |
申请公布日期 |
2001.02.08 |
申请号 |
WO2000US20247 |
申请日期 |
2000.07.26 |
申请人 |
MEDAREX, INC.;DEO, YASHWANT;GRAZIANO, ROBERT;HUDSON, DEBRA |
发明人 |
DEO, YASHWANT;GRAZIANO, ROBERT;HUDSON, DEBRA |
分类号 |
A01K67/027;A61K39/395;A61P13/08;A61P35/00;C07K16/28;C07K16/30;C07K16/46;C07K19/00;C12N5/10;C12N5/20;C12N15/02;C12N15/09;C12N15/85;C12P21/08;G01N33/574;G01N33/577;(IPC1-7):C07K16/30 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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