| 发明名称 |
HIGH AFFINITY TGF.GAMMA. NUCLEIC ACID LIGANDS AND INHIBITORS |
| 摘要 |
Methods are described for the identification and preparation of high-affinit y nucleic acid ligands to TGF.beta.2. Included in the invention are specific R NA ligands to TGF.beta.2 identified by the SELEX method. Also included are RNA ligands that inhibit the interaction of TGF.beta.2 with its receptor.</SDOAB >
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| 申请公布号 |
CA2380837(A1) |
申请公布日期 |
2001.02.08 |
| 申请号 |
CA20002380837 |
申请日期 |
2000.07.26 |
| 申请人 |
GILEAD SCIENCES, INC. |
发明人 |
LOCHRIE, MICHAEL;GOLD, LARRY;PAGRATIS, NIKOS |
| 分类号 |
C12N15/09;A61K9/127;A61K38/00;A61K47/48;A61P25/00;A61P31/00;A61P35/00;A61P35/04;A61P37/02;A61P43/00;C07B61/00;C07H19/06;C07H19/10;C07H21/00;C07K14/00;C07K14/49;C07K14/495;C07K14/50;C12N9/12;C12N15/10;C12N15/113;C12N15/115;C12Q1/37;C12Q1/68;C12Q1/70;F02B75/02;G01N33/531;G01N33/532;G01N33/535;G01N33/569;G01N33/68;G01N33/76;(IPC1-7):C07H21/02;C07H21/04 |
主分类号 |
C12N15/09 |
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