| 摘要 |
The present invention relates to reduced antigenicity tissue (RAT) implants, including bone implant materials comprising reduced antigenicity bone (RAB) and cartilage implant materials comprising reduced antigenicity cartilage (RAC) by virtue of having been treated to remove substantially all non-collagenous proteins from the bone or cartilage implant matrix. In specific applications of the invention the RAB and RAC implants are treated with osteogenic (osteoinductive or osteoconductive) or cartilage growth inducing compositions, including but not limited to bone morphogenic proteins, cartilage derived morphogenic proteins, growth factors, peptides, cells, natural or recombinant, expressing such proteins or growth factors, and expressible nucleic acids encoding such proteins, peptides, growth factors, or combinations thereof.
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