发明名称 |
DIAGNOSTIC SEQUENCING BY A COMBINATION OF SPECIFIC CLEAVAGE AND MASS SPECTROMETRY |
摘要 |
The present invention is in the field of nucleic acid-based diagnostic assays. More particularly, it relates to methods useful for the "diagnostic sequencing" of regions of sample nucleic acids for which a prototypic or reference sequence is already available (also referred to as "re-sequencing"), or which may be determined using the methods described herein. This diagnostic technology is useful in areas that require such re-sequencing in a rapid and reliable way: (i) the identification of the various allelic sequences of a certain region/gene, (ii) the scoring of disease-associated mutations, (iii) the detection of somatic variations, (iv) studies in the field of molecular evolution, (v) the determination of the nucleic acid sequences of prokaryotic and eukaryotic genomes; (vi) identifying one or more nucleic acids in one or more biological samples; (vii) and determining the expression profile of genes in a biological sample and other areas.
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申请公布号 |
WO0066771(A3) |
申请公布日期 |
2001.02.08 |
申请号 |
WO2000EP03904 |
申请日期 |
2000.04.30 |
申请人 |
METHEXIS N.V.;ZABEAU, MARC;STANSSENS, PATRICK |
发明人 |
ZABEAU, MARC;STANSSENS, PATRICK |
分类号 |
G01N27/62;C12N15/09;C12Q1/68;G01N33/53;G01N33/566;(IPC1-7):C12Q1/68 |
主分类号 |
G01N27/62 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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