发明名称 NEW CYTOTOXIC PYRIDO[2,3,4-KL]ACRIDINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE
摘要 The invention provides compounds of formula (I) wherein R1 represents a hydrogen atom, an alkyl group having from 1 to 6 carbon atoms, a hydroxy group, an alkoxy group having from 1 to 6 carbon atoms, a halogen atom, a nitro group, an amino group, a monoalkylamino group wherein the alkyl moiety has from 1 to 6 carbon atoms, a dialkylamino group wherein each alkyl moiety may be the same or different and each has from 1 to 6 carbon atoms, a monoalkoxyamino group wherein the alkoxy moiety has from 1 to 6 carbon atoms , a dialkoxyamino group wherein each alkoxy moiety may be the same or differen t and each has from 1 to 6 carbon atoms, an alkanoylamino group having from 1 to 20 carbon atoms or an alkanesulfonylamino group having from 1 to 6 carbon atoms; R2 represents a hydrogen atom or an alkyl group having from 1 to 6 carbon atoms; and R3 represents a hydrogen atom, an alkyl group having from 1 to 6 carbon atoms or an alkoxy group having from 1 to 6 carbon atoms; and pharmaceutically acceptable salts thereof. The compounds exhibit activity against a wide variety of mammalian cancer cell lines.
申请公布号 CA2380582(A1) 申请公布日期 2001.02.08
申请号 CA20002380582 申请日期 2000.07.27
申请人 UNIVERSIDAD DE BARCELONA 发明人 GARCIA GRAVALOS, DOLORES;FELIU, LIDIA;ALVAREZ, MERCEDES;FERNANDEZ-PUENTES, JOSE LUIS
分类号 A61K31/4375;A61P35/00;C07D471/06;(IPC1-7):C07D471/06;C07D221/00;A61K31/437 主分类号 A61K31/4375
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