RADIOLABELLED BISPHOSPHONATES AND METHOD

摘要

A method of making a bisphosphonate RC(OH)(PO.]OH]2)2 comprises reacting a tris(silyl)phosphite with an activated carbonyl compound and hydrolysing the resulting intermediate. Preferably the tris(silyl)phosphite is labelled with <32>P or <33>P. Radiolabelled bisphosphonates are used to treat patients suffering from osteosarcoma or bone metastases.