GENE ENCODING NOVEL SERINE PROTEASE-LIKE PROTEIN

摘要

By an oligocap method originally developed for isolating full-length cDNA, a plural number of full-length cDNAs are isolated from a human placental tissue cDNA library. Among these cDNAs, a clone (hC-PLACE1009992) encoding a novel serine protease-like protein is isolated. Further, a mouse cDNA (mC-PLACE1009992) corresponding to this human cDNA is successfully isolated too. C-PLACE1009992 shows a change in the expression in the brain of a patient with Alzheimer's disease compared with the brain of a normal subject, which suggests that it might relate to Alzheimer's disease.