NOVEL TACHYKININ PEPTIDES, PRECURSOR PEPTIDES THEREOF AND GENES ENCODING THE SAME

摘要

Tachykinin peptides isolated and purified from the posterior salivary gland of common octopus which is a mollusc. These tachykinin peptides, which provide a new approach for developing drugs and pesticides through studies on the structural activity correlation at the molecular level, are characterized by: (1) having 12 amino acid residues; (2) having Lys at the N-terminus; and (3) having the following amino acid sequence (I) consisting of 5 amino acids from the C-terminus: -Phe-Xaa-Gly-Leu-Met-NH2 wherein Xaa represents Val, Ile, Phe or Tyr. Among all, novel peptides having the following amino acid sequences (1) H-Lys-Pro-Pro-Ser-Ser-Ser-Glu-Phe-Val-Gly-Leu-Met-NH2; and (2) H-Lys-Pro-Pro-Ser-Ser-Ser-Glu-Phe-Ile-Gly-Leu-Met-NH2.