发明名称 |
NEW CYTOTOXIC PYRIDO[2,3,4-kl]ACRIDINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE |
摘要 |
The invention provides compounds of formula (I) wherein R<1> represents a hydrogen atom, an alkyl group having from 1 to 6 carbon atoms, a hydroxy group, an alkoxy group having from 1 to 6 carbon atoms, a halogen atom, a nitro group, an amino group, a monoalkylamino group wherein the alkyl moiety has from 1 to 6 carbon atoms, a dialkylamino group wherein each alkyl moiety may be the same or different and each has from 1 to 6 carbon atoms, a monoalkoxyamino group wherein the alkoxy moiety has from 1 to 6 carbon atoms, a dialkoxyamino group wherein each alkoxy moiety may be the same or different and each has from 1 to 6 carbon atoms, an alkanoylamino group having from 1 to 20 carbon atoms or an alkanesulfonylamino group having from 1 to 6 carbon atoms; R<2> represents a hydrogen atom or an alkyl group having from 1 to 6 carbon atoms; and R<3> represents a hydrogen atom, an alkyl group having from 1 to 6 carbon atoms or an alkoxy group having from 1 to 6 carbon atoms; and pharmaceutically acceptable salts thereof. The compounds exhibit activity against a wide variety of mammalian cancer cell lines.
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申请公布号 |
WO0109133(A1) |
申请公布日期 |
2001.02.08 |
申请号 |
WO2000GB02888 |
申请日期 |
2000.07.27 |
申请人 |
UNIVERSIDAD DE BARCELONA;RUFFLES, GRAHAM, KEITH;ALVAREZ, MERCEDES;FELIU, LIDIA;FERNANDEZ-PUENTES, JOSE LUIS;GARCIA GRAVALOS, DOLORES |
发明人 |
ALVAREZ, MERCEDES;FELIU, LIDIA;FERNANDEZ-PUENTES, JOSE LUIS;GARCIA GRAVALOS, DOLORES |
分类号 |
A61K31/4375;A61P35/00;C07D471/06;(IPC1-7):C07D471/06;A61K31/437 |
主分类号 |
A61K31/4375 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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