发明名称 |
PROCESS FOR PRODUCING A BASIC ANTIBIOTIC INORGANIC ACID SALT, AND OXALATE INTERMEDIATE |
摘要 |
An industrially excellent novel process for the preparation of addition salt s of basic antibiotics with inorganic acids (such as hydrochloric acid), by subjecting a basic antibiotic-oxalic acid addition salt (II) to salt-exchang e with an inorganic acid salt (III) of an alkaline earth metal, wherein A is a basic antibiotic; R10 is a protected functional group to be used in organic synthesis; Ak-E is an alkaline earth metal; and B is an inorganic acid; carbapenem derivative-oxalic acid addition salts represented by general formula (II-I) and being useful as intermediates for the preparation of hydrochlorides of antimicrobial agents; and a process for preparing the same , (II-I) wherein A is a three- to seven-membered ring having at least one nitrogen atom; R1 is hydrogen or the like; R2 and R5 are each hydrogen or a protecting group; R3 is a protecting group; R4 is hydrogen or the like; and R6 is hydrogen or the like.
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申请公布号 |
CA2379650(A1) |
申请公布日期 |
2001.02.08 |
申请号 |
CA20002379650 |
申请日期 |
2000.07.27 |
申请人 |
EISAI CO., LTD. |
发明人 |
NEGI, SHIGETO;SASHO, MANABU;SATO, NOBUAKI;KOMATSU, YUUKI;SAITO, HIROYUKI;KAYANO, AKIO;CHIBA, HIROYUKI;ISHIZUKA, HIROYUKI;SAKURAI, SHIN;NAKAMURA, TAIJU |
分类号 |
C07D477/02;C07D477/08;C07D477/20;C07D499/68;C07D501/22;C07D501/36;C07D501/46;(IPC1-7):C07D477/02;C07D463/00;C07D499/00;C07D501/00 |
主分类号 |
C07D477/02 |
代理机构 |
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主权项 |
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地址 |
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