| 摘要 |
PROBLEM TO BE SOLVED: To obtain the subject reconstruction agent which has an action on damaged and disordered structure-having skin to reconstruct its structure, by including a specific adenine derivative. SOLUTION: This agent for reconstructing dermal collagen fiber bundles contains an adenine derivative of the formula [R1 is a 4 to 16C unsaturated hydrocarbon which may contain oxygen in the substituent; R2 is H, a saccharide residue or a 1 to 4C alkyl; R3 is H, an (acylated) saccharide residue or a 1 to 4C alkyl; the dotted line is a combination of a double bond with a single bond] and/or its physiologically acceptable salt. The compound of the formula is preferably either of kinetin, trans-zeatin, cis-zeatin, trans-zeatin riboside and cis-trans-zeatin riboside. The compound of the formula may be extracted from a plant or synthesized from adenine and so on as raw materials. When the reconstructing agent is used for skin preparations for external use, the content of the reconstructing agent is preferably 0.001 to 5 wt.%, especially preferably 0.005 to 1 wt.%.
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