Method for the fermentative production of D-pantothenic acid using strains of the family enterobacteriaceae

摘要

A method for the production of D-pantothenic acid by the fermentation of microorganisms of the family Enterobacteriacae producing D-pantothenic acid which is characterized in that strains are used whicha) Contain the plasmid pFV31 and/or pFV202 and thatb) A panD gene and optionally other nucleotide sequences coding for aspartate-1-decarboxylase are enhanced, especially overexpressed in these microorganisms,c) The pantothenic acid is enriched in the medium or in the cells of the microorganisms andd) The pantothenic acid formed is isolated.