发明名称 |
Transgenic mouse expressing APP770-V717F |
摘要 |
Methods for screening for risk of Alzheimer's disease involve assaying for a guanine to thymine substitution at position 1924 of the gene encoding the human amyloid precursor protein. Also described are transgenic non-human mammals, especially transgenic mice, harboring an expressable gene sequence encoding human amyloid precursor protein having a phenyalanine for valine amino acid substitution in the transmembrane domain of the amyloid precursor protein.
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申请公布号 |
US6184435(B1) |
申请公布日期 |
2001.02.06 |
申请号 |
US19950475176 |
申请日期 |
1995.06.07 |
申请人 |
ADVANCED RESEARCH AND TECHNOLOGY INSTITUTE |
发明人 |
BENSON MERRILL D.;MURRELL JILL;FARLOW MARTIN;GHETTI BERNARDINO |
分类号 |
C07K14/47;C12N15/12;C12N15/85;C12Q1/68;(IPC1-7):A01K67/027;A01K67/033;G01N33/00 |
主分类号 |
C07K14/47 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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