发明名称 PRODUCTION OF HYDROXYPHENYLCYCLOHEXANONE DERIVATIVE
摘要 PROBLEM TO BE SOLVED: To obtain, through a simple process and in high selectivity/high yield, the subject compound having high purity and useful as an intermediate such as for a raw material for pharmaceuticals or industrial chemicals, by hydrogenating a specific substituted biphenol in the presence of a specific palladium catalyst in an organic solvent. SOLUTION: This compound of formula II [e.g. 4-(4'-hydroxyphenyl) cyclohexanone] is obtained by hydrogenating a substituted biphenol of formula I (R1 and R2 are each H or a 1-6C alkyl; m and n are each 0 to 2) [e.g. bis(4- hydroxyphenyl)] in the presence of a palladium catalyst in which 10-30 wt.% of palladium is supported on a carrier such as carbon in an organic solvent such as 2-butanol, preferably at pref. 110-160 deg.C, under a hydrogen pressure of 2-8 kg/cm2-G, for 3-7 h. It is desirable to use 0.2 to 2 pts.wt. of the above catalyst and 100 to 150 pts.wt. of the above solvent based on 100 pts.wt. of the compound of formula I.
申请公布号 JP2001031614(A) 申请公布日期 2001.02.06
申请号 JP19990201959 申请日期 1999.07.15
申请人 HONSHU CHEM IND CO LTD 发明人 SUGIYAMA KENJI;KITAURA TOYOKAZU;KAWASAKI SHINSAKU;EGAWA KENJI
分类号 B01J23/44;B01J23/58;C07B61/00;C07C45/00;C07C45/29;C07C45/62;C07C49/417;C07C49/517;C07C49/67;C07C49/747;C07C49/753;C07C315/04;C07C317/22;(IPC1-7):C07C45/29 主分类号 B01J23/44
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