发明名称 |
Stabilizing vitamin A derivatives by encapsulation in lipid vesicles formed with alkylammonium fatty acid salts |
摘要 |
The present invention provides for vitamin A derivative selected from the group consisting of retinol, retinyl ester and any combination thereof incorporated into liposomes formed with alkylammonium fatty acid salts, and methods for manufacturing same. The liposomes of the invention may deliver vitamin A derivative materials at the occurrence of a preset triggering condition. Preferred liposomes of the invention are cationic liposomes. The preferred liposomes of the invention are formed with alkylammonium fatty acid salts, e.g., trialkylammonium fatty acid salts of long chain amides. The encapsulated vitamin A derivative is thus stabilized by the liposomes. The present invention thus also provides a method of stabilizing vitamin A derivative be encapsulation in such liposomes. The liposomes of the invention are used to provide topical skin treatment formulations useful in the treatment of skin.
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申请公布号 |
US6183774(B1) |
申请公布日期 |
2001.02.06 |
申请号 |
US19990375683 |
申请日期 |
1999.08.17 |
申请人 |
COLLABORATIVE LABORATORIES, INC. |
发明人 |
AUST DUNCAN T.;ROSS MICHAEL A.;WILMOTT JAMES M.;HAYWARD JAMES A. |
分类号 |
A61K9/127;(IPC1-7):A61K9/127;A61K7/00 |
主分类号 |
A61K9/127 |
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