| 摘要 |
PROBLEM TO BE SOLVED: To obtain a specific diamino compound useful as a viral or bacterial neuraminidase inhibitor without using an azide reagent and azide intermediate through various reactions such as reaction between a specific epoxide and specific amine. SOLUTION: This compound of formula V is obtained by such processes that a compound of formula I (R1, R1', R2, and R2' are each H, an alkyl or the like, but only one of them is H) is reacted with a compound of the formula R5NHR6 (R5 and R6 are each H or an amino substituent, but both of them is not H at the same time) to form a compound of formula II, which is converted to a compound of formula III, which is converted to a compound of formula IV; the free-amino functional group at position 1 of the compound of formula IV is acylated to form the corresponding acylated 1,2-diamino compound and then the amino group at position 2 of the above diamino compound is freed; if necessary, the compound of formula V (R3 and R4 are each H or an amino substituent but both of them are not H at the same time) thus obtained is further converted to the corresponding pharmaceutically acceptable addition salt.
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