| 摘要 |
The invention describes compounds of the formulaand the pharmaceutically acceptable salts thereofand the pharmaceutically acceptable salts thereofwherein each R2 is independently a noninterfering substituent;m is an integer of 0-4;Z is CH or N;R1 is H, alkyl (1-6C) or arylalkyl optionally substituted on the aryl group with 1-3 substituents independently selected from alkyl (1-6C), halo, OR, NR2, SR, -OOCR, -NROCR, RCO, -COOR, -CONR2, -SO2NR2, CN, CF3, and NO2, wherein each R is independently H or lower alkyl (1-4C);n is 0, 1 or 2;Ar is phenyl, pyridyl, indolyl, or pyrimidyl, each optionally substituted with a group selected from the group consisting of optionally substituted alkyl (1-6C), halo, OR, NR2, SR, -OOCR, -NROCR, RCO, -COOR, -CONR2, SO2NR2, CN, CF3, and NO2, wherein each R is independently H or lower alkyl (1-4C); andR3 is a branched or cyclic alkyl group (5-7C) or is phenyl optionally substituted with 1-2 substituents which substituents are selected from the group consisting of alkyl (1-6C), halo, OR, NR2, SR, -OOCR, -NROCR, RCO, -COOR, -CONR2, -SO2NR2, CN, CF3, and NO2, wherein each R is independently H or lower alkyl (1-4C) which are useful as antiinflammatories and in treating cardiac disorders.
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