发明名称 |
Modified factor VII |
摘要 |
The catalytic active site of Factor VII is modified to produce a compound which effectively interrupts the blood coagulation cascade. The modifications render Factor VIIa substantially unable to activate plasma Factors X or IX. The invention relates to novel methods of treatment and uses of modified Factor VII for preventing or treating myocardial injury associated with post-ischemic reperfusion, for improving regional myocardial blood flow during reperfusion, and maintaining or improving vascular patency in a patient, as well as topical application of modified Factor VII at vascular sites susceptible to thrombus formation.
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申请公布号 |
US6183743(B1) |
申请公布日期 |
2001.02.06 |
申请号 |
US19990378907 |
申请日期 |
1999.08.20 |
申请人 |
ZYMOGENETICS, INC.;NOVO NORDISK A/S |
发明人 |
HART CHARLES E.;PETERSEN LARS C.;HEDNER ULLA;RASMUSSEN MIRELLA E. |
分类号 |
A61K38/48;(IPC1-7):A61K38/48;A61K35/14;C12N9/48;C12N9/64 |
主分类号 |
A61K38/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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