| 摘要 |
The present invention relates to building units suitable for the synthesis of backbone cyclized peptides. The building units of this invention have structures of Formula (I):wherein AAm and AAp are residues of natural or synthetic amino acids and U is CalphaON[(CH2)n+1W] or &PSgr;(CalphaH2N)[CO(CH2)qW], in which Calpha is a carbon atom and is the alpha carbon of AAm if m>0. W is NH-X or COY, and X is H, Boc, Z, Fmoc, or Alloc while Y is the hydroxyl group of a carboxylic acid moiety or a carboxylic acid protecting group. The letter m refers to an integer from 0 to 10; n is a number from 0 to 6; p is a number from 1 to 10; and q is a number from 1 to 6. The present invention is also directed to methods of synthesizing building units of Formula (I) via different routes.
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