| 摘要 |
Group B streptogramin derivatives (I) in 5 psi (R), 5 delta (S) and 5 psi (S),5 delta (R) forms, their mixtures, and their salts are new. Group B streptogramin derivatives of formula (I) in 5 psi (R), 5 delta (S) and 5 psi (S),5 delta (R) forms, their mixtures, and their salts are new. R = H, methyl, R'-CH2-, or acyl optionally substituted by OH; R' = straight or branched alkyl; R1, R2 = H or alkyl; Ra = methyl or ethyl; either Rb and Rc = H; and Rd = H, methylamino or dimethylamino; or Rb = H; Rc = H, Cl, Br or 3-5C alkenyl; and Rd = -NMe-R'; or R' = alkyl, hydroxyalkyl, or alkenyl (optionally substituted by phenyl, cycloalkylmethyl, benzyl (optionally substituted by one or more halo, OH, alkyl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, amino, alkylamino or dialkylamino groups), heterocyclylmethyl or heterocyclylethyl, the heterocycles being saturated or unsaturated of 5-6 members with 2 S, O, or N and optionally substituted by alkyl, alkenyl, cycloalkyl, heterocyclo, phenyl, or substituted phenyl), cyanomethyl, carboxymethyl, -CORe, or -CH2CORe; Re = alkylamino, alkyl methylamino, heterocyclylamino, or heterocyclyl methylamino, or OR'e; R'e = alkyl, alkenyl, benzyl or heterocyclylmethyl; or Rb = H; Rd = -NHCH3 or -N(CH3)2; Rc = Cl, Br or alkenyl if Rd is dimethylamino; or Rb, Rd = H; Rc = halo, alkylamino, dialkylamino, alkoxy, trifluoromethoxy, thioalkyl, alkyl, or trihalomethyl; or Rb and Rc = H; Rd = halo, ethylamino, diethylamino, methylethylamino, alkoxy, trifluoromethoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, alkyl, phenyl, or trihalomethyl; or Rb = H; Rc = halo, alkylamino, dialkylaminoalkoxy, trifluoromethoxy, thioalkyl, alkyl; Rd = halo, amino, alkylamino, dialkylamino, alkoxy, trifluoromethoxy, thioalkyl, alkyl, or trihalomethyl; or Rc = H; and Rb, Rd = methyl.
|
