| 摘要 |
Methods for treating conditions associated with hyperglycemia, especially Type II diabetes, with novel naphthylsulfonic acids and related compounds are provided. Compounds of formula (1) where: R<1> and R<2> are, independently, hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, R<3> is a substituent on the B ring; and is -SO2OR<6>, -C(O)OR<6>, -SO2NR<6>2-C(O)NR<6>2 or tetrazolyl; the linker -WY- between the naphthyl and phenyl intersects the A ring of the naphthyl and is, independently, -C(O)NR<7>-, -NR<7>C(O)-, -C(O)O-, -OC(O)-, -CH=CH-, -NR<7>CH2-, -CH2NR<7>-, -NR<7>C(O)NR<7>- -NR<7>C(O)O-, -OC(O)NR<7>-, -NR<7>SO2O-, -OSO2NR<7>-, -OC(O)O-, -SO2NR<7>-, -NR<7>SO2-, -OSO2-, or -SO2O-; each R<6> and R<7> is, independently, hydrogen or lower alkyl; optionally in the form of single stereoisomers or mixtures of stereoisomers, or the pharmaceutically acceptable salts thereof; are useful in methods of stimulating the kinase activity of the insulin receptor, enhancing the activation of the insulin receptor by insulin, and stimulating the uptake of glucose into cells. A variety of antidiabetic compounds and pharmaceutical compositions comprising the antidiabetic compounds are also disclosed. |
