<i>IN VIVO</i> INDUCTION FOR ENHANCED FUNCTION OF ISOLATED HEPATOCYTES
摘要
The invention features a liver cell culture comprising hepatocytes that have increased detoxification enzyme activity when isolated from a liver of a donor that had been administered at least one induction agent prior isolation of hepatocyte cells. The induced hepatocytes are used in a bioreactor and cultured to produce hepatocyte cell products or metabolize toxins added to the culture. The bioreactor is, or is an integral part of, a liver assist device used to treat a patient in need of liver assist.
申请公布号
WO0107069(A1)
申请公布日期
2001.02.01
申请号
WO2000US20113
申请日期
2000.07.24
申请人
ORGANOGENESIS INC.;SULLIVAN, SUSAN, J.;GREGORY, PAUL, G.;DIMILLA, PAUL, A.
发明人
SULLIVAN, SUSAN, J.;GREGORY, PAUL, G.;DIMILLA, PAUL, A.