| 摘要 |
Method of preparing a human recipient for a graft from a human, which include the use of anti-CD2 monoclonal antibody, administration of donor peripheral blood progenitor cells and a non-chronic course of an immunosuppressant (e.g. cyclosporine) and, optionally, performing a splenectomy. Possible variations are: whole body irradiation and/or chemotherapy plus thymic irradiation prior to induction of mixed chimerism; thymic irradiation exclusive of whole body irradiation prior to induction of mixed chimerism; administration of a blocker of the CD40-CD40L interaction and/or a blocker of the CD28-B7 interaction. |
